Proline metabolism as regulatory hub
WebOct 14, 2024 · The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic spread. Pyrroline ... WebApr 17, 2024 · Proline, as a substrate easily accessed from catabolized collagen, might be incorporated into several major metabolic pathways. α-Ketoglutarate (αKG), derived from proline, replenishes the TCA cycle in a process called anaplerosis [ 22 ].
Proline metabolism as regulatory hub
Did you know?
WebJan 7, 2024 · Dysregulated metabolism contributes to cancer initiation and progression, but the key drivers of these pathways are just being discovered. Here, we report a critical role for proline catabolism in ... WebProline plays important roles in protein synthesis and structure, metabolism (particularly the synthesis of arginine, polyamines, and glutamate via pyrroline-5-carboxylate), and nutrition, as well as wound healing, antioxidative reactions, and immune responses.
WebOct 16, 2024 · Transcriptome analysis reveals the proline metabolic pathway and its potential regulation TF-hub genes in salt-stressed potato Posted on 2024-10-16 - 22:35 Potato (Solanum tuberosum) is currently the third most important food crop in the world. WebOct 17, 2024 · Transcriptome analysis reveals the proline metabolic pathway and its potential regulation TF-hub genes in salt-stressed potato ... most DEGs identified from the “arginine and proline metabolism ...
Webbasis of regulation of proline metabolism is still largely obscure, the genetic engineering of proline content could lead to new opportunities to achieve plant stress tolerance. Additional key words: cross tolerance, free radicals, glutamate, ornithine, pentose phosphate pathway, proline metabolism. Introduction WebThe goal of this review is to describe the emerging knowledge on the role of Proline metabolism, mainly Proline synthesis, in the control of cancer cell plasticity, the genes/enzymes/pathways involved and their relevance as prognostic markers and potential therapeutic targets.
WebJan 26, 2024 · “Arginine and proline metabolism (map00330)” and “carbon metabolism” were the highly enriched pathways in the L1 vs. L2 and L2 vs. P comparison groups, respectively. Stage-specific and shared functional annotations of DE circRNAs and DE miRNAs were obtained by conducting Venn analysis.
WebLiu, G., Zhang, Y., Yun, Z., Hu, M., Liu, J., Jiang, Y., & Zhang, Z. (2024). Melatonin Enhances Cold Tolerance by Regulating Energy and Proline Metabolism in Litchi ... fishing in fife scotlandWebProline is a multifunctional amino acid that is accumulated in high concentrations in plants under various stress conditions. Proline accumulation is intimately connected to many … can blind people hallucinateWebApr 21, 2024 · Proline availability is regulated by prolidase (proline supporting enzyme), collagen biosynthesis (proline utilizing process) and proline synthesis from glutamine, … fishing in finland typing testWebThe regulatory functions of proline metabolism proposed 3 decades ago have found relevance in many areas. For cancer, these functions play a role in apoptosis, autophagy and in response to nutrient and oxygen deprivation. Importantly, proline-derived reactive oxygen species served as a driving signal for reprogramming. This model has been ... can blind people drive legallyWebAug 5, 2024 · Proline is a multifunctional amino acid that is accumulated in high concentrations in plants under various stress conditions. Proline accumulation is … can blind people cycleWebProline metabolism is coordinated with various metabolic pathways in different cellular compartments and integrates redox and energy balance, growth, and defense regulation. … can blind people feel colorWebMay 9, 2024 · Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via … can blind people drive tesla