WebJun 15, 2024 · Here, we describe the identification of a novel series of potent and selective small molecule inhibitors of KIF18A MT-ATPase motor activity exemplified by AM-1882, … WebThis patent search tool allows you not only to search the PCT database of about 2 million International Applications but also the worldwide patent collections. This search facility features: flexible search syntax; automatic word stemming and relevance ranking; as well as graphical results.
Sci-Hub Novel Amide Compounds as KIF18A Inhibitors for Treating …
WebMar 7, 2024 · Volastra Therapeutics announced Tuesday it has in-licensed Amgen’s Phase I candidate sovilnesib, a KIF18A inhibitor being studied for high-grade ovarian cancer, triple-negative breast cancer and other solid tumors. Concurrently, the New York-based biotech has secured $60 million in Series A funding. The financing round was led by Eli Lilly ... WebMonopolar spindle kinase 1 (Mps1) is a key element of the mitotic checkpoint and clinically evaluated as a target in the treatment of aggressive tumors. With this aim, a set of pyrazolo[3,4-b]pyridine-based compounds as new Mps1 inhibitors was investigated through a multidisciplinary approach, based … d2 sorc fcr breaks
Volastra Therapeutics In-Licenses Clinical Stage KIF18A Inhibitor …
WebOct 21, 2024 · The reliance of tumor cells on aerobic glycolysis is one of the emerging hallmarks of cancer. Pyruvate kinase M2 (PKM2), an important enzyme of glycolytic pathway, is highly expressed in a number of cancer cells. Tumor cells heavily depend on PKM2 to fulfill their divergent energetic and biosynthetic requirements, suggesting it as … WebMar 7, 2024 · Volastra Therapeutics In-Licenses Clinical Stage KIF18A Inhibitor and Secures $60 Million in Series A Funding to Further Advance Cancer-Focused Pipeline Financing led by founding investors... WebAs tetraploidization or whole genome doubling has been linked to large percentages of cancer types, this dependence on KIF18A has been proposed as a possible therapeutic … bingocraft