Web11 de abr. de 2024 · Currently, high doses of cytarabine arabinoside (Ara-C)-based combined chemotherapy are commonly used in acute myeloid leukemia (AML) therapy, but severe adverse effects and poor suppression effects in leukemia cells limit the clinical therapeutic efficiency of Ara-C-based chemotherapy due to a lack of targeting selectivity. … WebCytarabine (also called cytosine arabinoside or Ara-C) is a treatment for leukaemia, particularly acute myeloid leukaemia (AML). It can be administered at different doses, generally referred to as ‘high’, ‘intermediate’ and ‘low’. High and intermediate dose cytarabine are generally used as part of the intensive chemotherapy treatment
Intermediate-Dose Cytarabine in the Treatment of Relapsed or
Web25 de jan. de 2024 · Older or unfit patients, however, often do not endure a high dose remission initiating treatment. Thus, those patients benefit more from receiving low-dose Ara-C or hypomethylating agents like decitabine and azacitidine (5-Aza), which was initially approved for treatment of myelodysplastic syndrome (MDS) [20, 21]. Web20 de nov. de 2024 · Alternatively, a higher dose of 3.0mg/kg daunorubicin and 75mg/kg Ara-C was used (high dose DA therapy). For some experiments, doxorubicin was … dichanthelium xanthophysum
Efficacy and safety of different doses of cytarabine in
WebThe aim of this study is to determine whether the addition of mitoxantrone to high dose cytarabine improves the outcome of treatment in patients ... Patients achieving complete … Web8 de jul. de 2024 · Currently, the standard induction of primary central nervous system lymphoma (PCNSL) is high-dose methotrexate (HD-MTX)-based chemotherapy [1, 2].Addition of high-dose cytarabine (HD-Ara-C) to HD-MTX 3.5 g/m 2 followed by whole-brain radiotherapy (WBRT) led to a significantly higher complete response rate (46% vs … WebR-HDAC, or R-HD-AraC (ituximab plus (H)igh (D)ose ra-) is a chemotherapy regimen that is used, alternating with R-Maxi-CHOP, as part of so-called "Nordic protocol" of treating mantle cell lymphoma.It consists of monoclonal antibody rituximab and high-dose antimetabolite cytarabine.. High-dose Ara-C (HDAC) without rituximab also has several other uses in … citizen consumer loan servicing