Context sensitive half time calculator
WebApr 5, 2024 · The estimated context-sensitive half time of dexmedetomidine is favourably short at between 1 and 4 hours. 3 Thus, the elimination half-life is similar following a single dose or infusions of more than 24 hours. A summary of the pharmacokinetics of dexmedetomidine can be found in Table 1. WebThe context-sensitive half-time often cannot be predicted by the elimination half-life (a measure of the time needed for actual drug metabolism or elimination) since it also depends on drug distribution. The context-sensitive half-time is a function of the duration of drug administration and may only be estimated by computer simulation.
Context sensitive half time calculator
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WebEdit. View history. Context-sensitive half-life or context sensitive half-time is defined as the time taken for blood plasma concentration of a drug to decline by one half after an … WebMar 20, 2010 · 32. Mar 18, 2010. #6. pgg said: Half time = half life. Both terms refer to how much time will pass until 1/2 of the substance has been cleared from the site of action (by metabolism, excretion, or redistribution). "Elimination" usually implies that the drug is gone (metabolized or excreted, never to return) but there's some ambiguity to the term.
WebAug 16, 2003 · The 50% decrease in drug concentration after the end of administration was more predicted by the context-sensitive half-time than by the elimination half-life. By computer simulations of sufentanil decay Shafer et al [ 18 ]. calculated that a 50% decrease in the effect-site concentration would take 0.8 h after a 10 h infusion. WebTherapeutic Effects:Analgesia Anesthesia Implications Potency – 5-10 times more potent than Fentanyl Context-sensitive half-time (CSHT) – for continuous infusions, Sufenta …
WebOct 22, 2024 · Context-sensitive half time is the concept which relates the drug distribution into and out of tissue compartments to the change in plasma concentration after sustained infusion. If the infusion has not … WebApr 2, 2024 · The context sensitive half time (T1/2) of dexmedetomidine can range from 4 min after a 10-min infusion . Context sensitive time half time (T1/2) can be over 4 h after a prolonged 8-h infusion. Clearance of dexmedetomidine matures with age reaching maturity at 1 year of age and is reduced by 27% after a cardiac surgery . …
WebSep 13, 2012 · The context-sensitive half-time is the time required for blood or plasma concentrations of a drug to decrease by 50% after discontinuation of drug administration. The context-sensitive half-time often cannot be predicted by the elimination half-life (a measure of the time needed for actual drug metabolism or elimination) since it also …
WebMay 1, 2024 · The context-sensitive half-time reflects the cumulative effects of these factors. This concept is marked with lipophilic drugs like thiopental, diazepam, and … Context-Sensitive Half-Time. Next article. Beginning My Last Month Of Regional … The context-sensitive half-time reflects the cumulative effects of these factors. This … maxiumfix wirelessWebAlfentanil has the most rapid analgesic onset and time to peak effect as well as the shortest distribution and elimination half-lives. ... Although comparing specific pharmacokinetic parameters such as half-lives is deeply entrenched in the literature and clinical practice, simply comparing half-lives is not a rational way to select an opioid ... maxium handsizeWebThe context-sensitive half-time is derived from computer modelling using known pharmacokinetic parameters. The modelled context-sensitive half-time for a 3-h … heroes 3 cheatyWebElimination – metabolites excreted renally (95%) and in faeces (4%); context-sensitive half-life varies from 4 min for a 10 min infusion to 250 min for an 8 h infusion; ... Bellomo … heroes 3 cestinaWebJun 1, 2004 · Propofol has a context-sensitive half-time that varies between 3 min for a very short infusion to about 18 min after a 12-h … maxium fitness newark ohWebContext-sensitive half-time provides more useful information under these circumstances. If a drug is given as a constant rate infusion, steady-state concentration will only be achieved after four to five half-lives. Partial pressure largely determines the behaviour of … heroes 3 chroniclesWebJun 30, 2015 · This chapter answers parts from Section B(v) of the 2024 CICM Primary Syllabus, which expects the exam candidate to "describe the concepts of effect-site and … heroes 3 complete cheaty