Cisplatin and aki and autophagy

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WebJan 22, 2024 · Cisplatin treatment may activate toll-like receptors 2 in renal tubular cells, which further activates autophagy via the phosphorylate phosphoinositide 3-kinase … WebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, …

Frontiers Kidney-Targeted Redox Scavenger Therapy Prevents Cisplatin …

Web1 day ago · In this study, a natural product from Osage Orange, pomiferin, was identified as a novel autophagy activator that circumvents innate resistance by triggering autophagic cell death via SERCA inhibition and activation of the CaMKKβ-AMPK-mTOR signaling cascade. In addition, pomiferin also directly inhibited the P-gp (MDR1/ABCB1) efflux and ... WebDec 12, 2024 · Cisplatin can induce AKI through ischemic damage, by reducing the blood flow in the medulla of the kidneys leading to tubular cell injury. Vasoconstriction due to … d4 dance video songs download

Frontiers AMPK/mTOR Signaling in Autophagy Regulation During

WebOct 13, 2024 · Cisplatin-induced acute kidney injury (AKI), characterized by rapid loss of renal function within days of initiating treatment, occurs in around 30% of patients who are receiving cisplatin ... WebDec 21, 2024 · Myo-inositol, a carbocyclic sugar, is believed to be relevant to renal pathobiology since the kidney is the major site for its catabolism. Its role in acute kidney injury (AKI) has not been fully investigated. Ferroptosis, a unique form of regulated cell death, is involved in various types of renal injuries. The relevance of myo-inositol with … WebIn AKI mice induced by injection of a single dose of cisplatin (15 mg/kg), oral administration of kaempferide (50 mg/kg) either before or after cisplatin injection markedly improved renal function, and ameliorated renal tissue damage. bing our services aren\u0027t available right now

Roles of Reactive Oxygen Species and Autophagy in the …

PIM1激酶在顺铂诱导的急性肾损伤中的作用

WebFeb 2, 2024 · Some scholars have found that in the cisplatin-induced AKI mice, the C. cicadae mycelium extract regulated the inflammatory response by inhibiting renal pathological changes, inflammatory cell infiltration, and the release of a variety of inflammatory cytokines such as TNF-α, IL-1β, and IL-6. WebApr 25, 2014 · The role of autophagy in cisplatin-induced AKI is discussed in the next section. 4.2. Autophagy Autophagy is a cellular process of “self-eating” in which … d4 dance winnerWebFeb 24, 2024 · During autophagy-dependent cell death, extensive vacuolization of the cytoplasm is formed; the integrity of the plasma membrane is lost; and sometimes, enlargement of the Golgi and ER is observed... bingo used cars

"WebNov 30, 2024 · In this study, we investigated whether canagliflozin protects against cisplatin-induced AKI, depending on adenosine monophosphate-activated protein kinase (AMPK) activation and following... " - Cisplatin and aki and autophagy

Cisplatin and aki and autophagy

Metformin Protects Against Cisplatin-Induced Tubular Cell ... - PubMed

WebApr 6, 2024 · Therefore, it is particularly important to find drugs that have therapeutic effect against cisplatin ototoxicity. Autophagy is a cell metabolic process in which cells degrade their components within lysosomes (or vacuoles) to maintain normal physiological activities and homeostasis ( 7 ). WebMar 23, 2024 · Here, we postulated that systemically delivered rapamycin perfluorocarbon nanoparticles (PFC NP) could reach the injured kidneys at sufficient and sustained concentrations to mitigate cisplatin-induced acute kidney injury and preserve renal function. Using fluorescence microscopic imaging and fluorine magnetic resonance …

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WebAug 7, 2024 · Mitophagy is a mechanistically elaborate process including (a) mitophagy initiation, (b) priming of mitochondria for recognition by autophagy machinery, (c) engulfment of the marked mitochondria by formation of the autophagosome, and (d) lysosomal sequestration and hydrolytic degradation ( Figure 1; Vasquez-Trincado et al., … WebOct 14, 2024 · Cisplatin is an inorganic platinum-based drug that was FDA approved as an anticancer agent in 1978.1It is a standard therapy used to treat many solid organ …

WebJul 7, 2024 · The nephrotoxicity of cisplatin remains a major hurdle in the field of oncology. 30% of patients treated with cisplatin develop acute kidney injury (AKI) and all patients … WebJan 10, 2024 · Cisplatin, a chemotherapeutic agent approved by the United States Food and Drug Administration in 1978, is used in the treatment of various solid organ malignancies [ 13 ]. However, ~30% of...

WebApr 7, 2016 · Blockade of either AMPKα activation or autophagy induction could largely abolish the protective effect of metformin in cisplatin-induced cell death. Together, this study demonstrated that metformin may protect against cisplatin-induced tubular cell apoptosis and AKI through stimulating AMPKα activation and autophagy induction in … WebAug 6, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and …

WebCisplatin, a chemotherapeutic agent, is a known nephrotoxin and can cause AKI. The cisplatin treatment induces a time-dependent increase in the LC3 expression in proximal tubular epithelial cells. 23 The inhibition of autophagy through either treatment with 3-MA or knockdown of Becn1 by short-hairpin RNA or siRNA, or Atg5 by siRNA resulted in ...

WebApr 27, 2024 · Aims:Cisplatin, an anticancer drug, always leads to nephrotoxicity by causing mitochondrial dysfunction. As a major mechanism for cellular self-degradation, autophagy has been proven to protect against cisplatin … d4dj call of artemis do the dive flac 4hzWebNov 26, 2024 · The inhibition of cisplatin-induced autophagy increases cisplatin-induced apoptosis, suggesting the synergistic induction on cancer cell death via inhibiting cisplatin-induced autophagy activity [39,43]. Thus, through the inhibition of chemotherapy-induced autophagy, ginkgolic acids can enhance the sensitivity of cancer cells to chemotherapy. d4-dexamethasoneWebAutophagy is a conserved multistep pathway that degrades and recycles damaged organelles and macromolecules to maintain intracellular homeostasis. The … bingo u of mWebCisplatin-induced acute kidney injury in mice was established by intraperitoneal injection of cisplatin. The levels of urea nitrogen and creatinine in serum were measured， renal pathology change was assayed by HE staining， qRT-PCR and Western blot were used to detect the expression levels of PIM1 mRNA and PIM1 protein. bingo under the seaWebThe delivery of an approved agent such as rapamycin in a PFC NP format enhances local delivery and offers a novel mechanism-based prophylactic therapy for cisplatin-induced acute kidney injury. For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10–20% of all cancer patients. … d4 dictionary\u0027sWebNov 3, 2024 · The kidney injury caused by cisplatin can present in a variety of ways. As it was clearly proved in some researches, the most serious and common damage induced by cisplatin is acute kidney injury (AKI) … bingo und rolly ausmalbilderWebFeb 18, 2024 · Cisplatin, a platinum-based compound, is a commonly used and highly effective chemotherapeutic agent utilized for the treatment of a variety of solid tumors. … bingo used tires